Fibrillary glomerulonephritis in a Peruvian patient: partial functional remission after immunosuppression in a regional hospital

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DOI:

https://doi.org/10.35563/rmp.v14i2.654

Keywords:

nephrotic syndrome, fibrillary glomerulonephritis, hemodialysis, mycophenolate, hepatitis C

Abstract

ABSTRACT

Introduction: Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by non-Congo red-reactive fibrillar deposits, diagnosed definitively by electron microscopy.

Case presentation: We report a 59-year-old Peruvian male presenting with progressive renal failure and nephrotic syndrome requiring hemodialysis. Renal biopsy and electron microscopy revealed fibrillary deposits in glomeruli, mesangium, and tubules. Hepatitis C virus (HCV) serology was initially positive but active infection was excluded by negative viral load. Immunosuppressive therapy with prednisone and mycophenolate mofetil was initiated.

Clinical outcome: After six months, partial renal recovery and remission of proteinuria allowed withdrawal from dialysis. At 24 months, renal function remains stable with no significant relapse.

Conclusion: FGN may show favorable response to immunosuppression in selected cases without monoclonal gammopathy or active infection, highlighting the importance of early diagnosis and sustained follow-up.

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Published

2025-08-03

Issue

Vol. 14 No. 2 (2025): May - August

Section

CASE REPORTS

License

Copyright (c) 2025 Cruzalegui-Gómez Cesar Eduardo, Berrocal-Salcedo Juan Carlos, Cuba-Ramos Henry Wilfredo, Miserendino Diana María

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How to Cite

Fibrillary glomerulonephritis in a Peruvian patient: partial functional remission after immunosuppression in a regional hospital. (2025). Revista Médica Panacea, 14(2), 95-102. https://doi.org/10.35563/rmp.v14i2.654